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TitleTissue perfusion measurements: Multiple-exposure laser speckle analysis generates laser doppler-like spectra
Publication TypeJournal Article
Year of Publication2010
AuthorsThompson, O.B., and Andrews M.K.
JournalJournal of Biomedical Optics
Date Published2010
ISSN10833668 (ISSN)
Keywordsalgorithm, Algorithms, article, Biomedical optics, Blood, Brownian movement, Classifiers, computer assisted diagnosis, computer simulation, Diagnosis, Computer-Assisted, Doppler effect, human, Humans, Image quality, instrumentation, Laser doppler, laser Doppler flowmetry, Laser speckle, Laser speckle contrast analysis, Laser speckle perfusion imaging, Laser-Doppler Flowmetry, methodology, Perfusion, Perfusion Imaging, Phantoms, Imaging, Power spectral density, reproducibility, Reproducibility of Results, scintigraphy, sensitivity and specificity, Speckle, Spectral density, Tissue
AbstractVariations in skin perfusion are easily detected by laser speckle contrast maps, but a robust interpretation of the information has been lacking. We show that multiple-exposure laser speckle methods produce the same spectral information as laser Doppler methods when applied to targets with embedded moving scatterers. This enables laser speckle measurements to be interpreted more quantitatively. We do this by using computer simulation of speckle data, and by experimental measurements on Brownian motion and skin perfusion using a laser Doppler system and a multiple-exposure laser speckle system. The power spectral density measurements of the light fluctuations derived using both techniques are exactly equivalent. Dermal perfusion can therefore be measured by laser Doppler or laser speckle contrast methods. In particular, multiexposure laser speckle can be rapidly processed to generate a full-field map of the perfusion index proportional to the concentration and mean velocity of red blood cells. © 2010 Society of Photo-Optical Instrumentation Engineers.

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