| Title | The synthesis of possible transition state analogue inhibitors of thymidine phosphorylase |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Evans, G.B., Gainsford G.J., Schramm V.L., and Tyler P.C. |
| Journal | Tetrahedron Letters |
| Volume | 56 |
| Issue | 2 |
| Pagination | 406 - 409 |
| Date Published | 2015 |
| ISSN | 00404039 (ISSN) |
| Keywords | 2 deoxyribose, angiogenesis, article, carbocyclic thymidine, chemical reaction, chromatography, crystal structure, debenzylation, deoxygenation, drug synthesis, enzyme chemistry, enzyme inhibitor, human, hydroboration, isomer, nucleophilicity, ophthalmic femtosecond laser, phosphonic acid derivative, protein purification, stereochemistry, synthesis, thymidine phosphorylase, thymidine phosphorylase inhibitor, unclassified drug |
| Abstract | The synthetically challenging SN2 transition state mimic for thymidine phosphorylase, along with its phosphonate analogue, were synthesised via a modified Corey-Link reaction in good overall yields and ensuring the correct stereochemical outcome. © 2014 Elsevier Ltd. All rights reserved. |
| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-84922228338&partnerID=40&md5=07144b089ff7564231faf97e6f1cf4cf |
| DOI | 10.1016/j.tetlet.2014.11.113 |
