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TitleThe synthesis of possible transition state analogue inhibitors of thymidine phosphorylase
Publication TypeJournal Article
Year of Publication2015
AuthorsEvans, G.B., Gainsford G.J., Schramm V.L., and Tyler P.C.
JournalTetrahedron Letters
Pagination406 - 409
Date Published2015
ISSN00404039 (ISSN)
Keywords2 deoxyribose, angiogenesis, article, carbocyclic thymidine, chemical reaction, chromatography, crystal structure, debenzylation, deoxygenation, drug synthesis, enzyme chemistry, enzyme inhibitor, human, hydroboration, isomer, nucleophilicity, ophthalmic femtosecond laser, phosphonic acid derivative, protein purification, stereochemistry, synthesis, thymidine phosphorylase, thymidine phosphorylase inhibitor, unclassified drug
AbstractThe synthetically challenging SN2 transition state mimic for thymidine phosphorylase, along with its phosphonate analogue, were synthesised via a modified Corey-Link reaction in good overall yields and ensuring the correct stereochemical outcome. © 2014 Elsevier Ltd. All rights reserved.

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