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TitleSpectral density and tissue perfusion from speckle contrast measurements
Publication TypeConference Paper
Year of Publication2008
AuthorsThompson, O.B., and Andrews M.K.
Conference NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Date Published2008
Keywords(p ,p ,t) measurements, Auto correlation function (ACF), Blood flows, Camera technology, Characteristic time, Coherent light, Computer networks, contrast measurements, Correlation detectors, Diagnostic radiography, Doppler, exposure time, Hemodynamics, Imaging techniques, laser speckles, Lasers, Measurements, Medical imaging, Nonexponential, Optical engineering, Optical methods, Optical tomography, Optical-coherence tomography (OCT), Optics, Pulsed laser deposition, Regression analysis, Speckle, Spectral informations, Technology, Technology transfer, Thermography (temperature measurement), Tissue perfusion, Tomography
AbstractProgress in laser and camera technology has simplified the acquisition of laser speckle images relating to dermal blood flow. Using speckle contrast measurements over 5 decades of exposure time, we show that a temporal autocorrelation function, and hence spectral information and a perfusion index precisely equivalent to that produced in Doppler methods, can be derived from speckle measurements. The autocorrelation data are well approximated by a simple but nonexponential function which is parametric in a characteristic time τc. We suggest that the perfusion index could be found simply by determining τc from a small number of speckle measurements at appropriate exposures. This is illustrated by measurement of perfusion recovery following an induced change in perfusion.

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