| Title | Screening of New Zealand plant extracts for inhibitory activity against HIV-1 protease |
| Publication Type | Journal Article |
| Year of Publication | 1996 |
| Authors | Wan, M., Bloor S.J., Foo L.-Y., and Loh B.-N. |
| Journal | Phytotherapy Research |
| Volume | 10 |
| Issue | 7 |
| Pagination | 589 - 595 |
| Date Published | 1996 |
| ISSN | 0951418X (ISSN) |
| Keywords | alcohol, article, Cassinia, Cassinia leptophylla, concentration response, controlled study, Elaeocarpus, Elaeocarpus hookerianus, enzyme inhibition, fluorescence, high performance liquid chromatography, Human immunodeficiency virus, human immunodeficiency virus 1, new zealand, nonhuman, Pernettya, plant extract, proteinase, proteinase inhibitor, Pseudotsuga menziesii, screening, virus enzyme |
| Abstract | 231 Ethanol/aqueous extracts from New Zealand plants were screened for inhibitory activity against HIV-1 protease using fluorogenic and HPLC assays. Among the examined extracts, Pseudotsuga menziesii, Elaeocarpus hookerianus, Pernettya macrostigma and Cassinia leptophylla showed significant inhibition at a concentration of 50 μg/mL in the HPLC confirmation assay. The IC 50 values of these extracts to HIV-1 protease on its synthetic peptide substrate were 9.63, 9.74, 27.62 and 60.73 μg/mL, respectively. The derivatives of dihydroquercetin and [5'5']-bisdihydroquercetin from Pseudotsuga menziesii could be the causative compounds for the inhibition. |
| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-0029802557&partnerID=40&md5=77730b1c38ee46882d6a29784941afb5 |
| DOI | 10.1002/(SICI)1099-1573(199611)10:7<589::AID-PTR910>3.0.CO;2-# |
