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TitleScreening of New Zealand plant extracts for inhibitory activity against HIV-1 protease
Publication TypeJournal Article
Year of Publication1996
AuthorsWan, M., Bloor S.J., Foo L.-Y., and Loh B.-N.
JournalPhytotherapy Research
Pagination589 - 595
Date Published1996
ISSN0951418X (ISSN)
Keywordsalcohol, article, Cassinia, Cassinia leptophylla, concentration response, controlled study, Elaeocarpus, Elaeocarpus hookerianus, enzyme inhibition, fluorescence, high performance liquid chromatography, Human immunodeficiency virus, human immunodeficiency virus 1, new zealand, nonhuman, Pernettya, plant extract, proteinase, proteinase inhibitor, Pseudotsuga menziesii, screening, virus enzyme
Abstract231 Ethanol/aqueous extracts from New Zealand plants were screened for inhibitory activity against HIV-1 protease using fluorogenic and HPLC assays. Among the examined extracts, Pseudotsuga menziesii, Elaeocarpus hookerianus, Pernettya macrostigma and Cassinia leptophylla showed significant inhibition at a concentration of 50 μg/mL in the HPLC confirmation assay. The IC 50 values of these extracts to HIV-1 protease on its synthetic peptide substrate were 9.63, 9.74, 27.62 and 60.73 μg/mL, respectively. The derivatives of dihydroquercetin and [5'5']-bisdihydroquercetin from Pseudotsuga menziesii could be the causative compounds for the inhibition.

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