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TitleA rapid, inexpensive surface treatment for enhanced functionality of polydimethylsiloxane microfluidic channels
Publication TypeJournal Article
Year of Publication2012
AuthorsBeal, J.H.L., Bubendorfer A., Kemmitt T., Hoek I., and Arnold W.M.
Date Published2012
ISSN19321058 (ISSN)
Keywords3-aminopropyltriethoxysilane, Alkoxysilanes, Amine functionality, Chemical derivatization, chemical modification, Electroosmosis, Electroosmotic, Electroosmotic flow, Fluidic devices, High-throughput, Micro-fluidic devices, Microchannels, Microfluidic channel, PDMS surfaces, Polydimethylsiloxane PDMS, Rapid prototyping, Selective modification, Silicones, Specific areas, Stable surface layer, Surface layers, Wetting
AbstractA rapid, inexpensive method using alkoxysilanes has been developed to selectively coat the interior of polydimethylsiloxane (PDMS) microfluidic channels with an integral silicaceous layer. This method combines the rapid prototyping capabilities of PDMS with the desirable wetting and electroosmotic properties of glass. The procedure can be carried out on the open faces of PDMS blocks prior to enclosure of the channels, or by flowing the reagents through the preformed channels. Therefore, this methodology allows for high-throughput processing of entire microfluidic devices or selective modification of specific areas of a device. Modification of PDMS with tetraethoxysilane generated a stable surface layer, with enhanced wettability and a more stable electroosmotic flow rate than native PDMS. Modification of PDMS with 3-aminopropyltriethoxysilane generated a surface layer bearing amine functionalities allowing for further chemical derivatization of the PDMS surface. © 2012 American Institute of Physics.

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