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TitlePreparation and characterization of progesterone dispersions using supercritical carbon dioxide
Publication TypeJournal Article
Year of Publication2014
AuthorsFalconer, J.R., Wen J., Zargar-Shoshtari S., Chen J.J., Farid M., Tallon S.J., and Alany R.G.
JournalDrug Development and Industrial Pharmacy
Volume40
Issue4
Pagination458 - 469
Date Published2014
ISSN03639045 (ISSN)
Keywordsalpha tocopherol succinate, article, Carbon dioxide, Chemistry, Pharmaceutical, controlled study, crystal structure, crystallin, Crystallization, dispersion, drug solubility, excipient, Excipients, gelucire, high performance liquid chromatography, in vitro study, Infrared spectroscopy, liquid chromatography, macrogol 10000, macrogol 400, macrogol 4000, melting point, performance, Polyethylene Glycols, progesterone, Raman spectrometry, Scanning electron microscopy, Solubility, solvent, succinic acid, supercritical fluid, suspension, Time Factors, Vitamin E, X ray powder diffraction
AbstractContext: Supercritical fluid methods offer an alternative to conventional mixing methods, particularly for heat sensitive drugs and where an organic solvent is undesirable. Objective: To design, develop and construct a unit for the particles from a gas-saturated suspension/solution (PGSS) method and form endogenous progesterone (PGN) dispersion systems using SC-CO2. Materials and methods: The PGN dispersions were manufactured using three selected excipients: polyethylene glycol (PEG) 400/4000 (50:50), Gelucire 44/14 and D-α-tocopheryl PEG 1000 succinate (TPGS). Semisolid dispersions of PGN prepared by PGSS method were compared to the conventional methods; comelting (CM), cosolvent (CS) and physical mixing (PM). The dispersion systems made were characterized by Raman and Fourier transform infrared (FTIR) spectroscopies, X-ray powder diffraction (XRPD), scanning electron microscopy (SEM), PGN recovery, uniformity and in vitro dissolution, analyzed by high-performance liquid chromatography (HPLC). Results: Raman spectra revealed no changes in the crystalline structure of PGN treated with SC-CO2 compared to that of untreated PGN. XRPD and FTIR showed the presence of peaks and bands for PGN confirming that PGN has been incorporated well with each individual excipient. All PGN dispersions prepared by the PGSS method resulted in the improvement of PGN dissolution rates compared to that prepared by the conventional methods and untreated PGN after 60 min (p value
URLhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84896709990&partnerID=40&md5=15a67490b178c7ed03231c8d7096fa7f
DOI10.3109/03639045.2013.768630

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