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TitleA flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3- dihydroimidazo[4,5-c]pyridin-2-one core
Publication TypeJournal Article
Year of Publication2011
AuthorsHay, D.A., Adam F.M., Bish G., Calo F., Dixon R., Fray M.J., Hitchin J., Jones P., Paradowski M., Parsons G.C., Proctor K.J.W., Pryde D.C., and Smith N.N.
JournalTetrahedron Letters
Pagination5728 - 5732
Date Published2011
ISSN00404039 (ISSN)
Keywords4 amino 1,3 dihydroimidazo[4,5 c]pyridin 2 one derivative, article, carbamic acid derivative, carbonyl derivative, catalysis, cross coupling reaction, cyclization, debenzylation, diazotization, hydrogenation, microwave irradiation, Negishi cross coupling reaction, nitration, pyridone derivative, Reduction, Stille reaction, unclassified drug
AbstractA flexible route which enables access to derivatives of 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-ones is described. Issues of selectivity, reaction safety, and low yields in original routes are overcome with the key improvements to the route, including a Negishi cross-coupling and use of a carbamate as a protecting group and intrinsic carbonyl source. The new route enables variation of C-6 and N-1 substituents © 2011 Elsevier Ltd. All rights reserved.

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