| Title | A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3- dihydroimidazo[4,5-c]pyridin-2-one core |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Hay, D.A., Adam F.M., Bish G., Calo F., Dixon R., Fray M.J., Hitchin J., Jones P., Paradowski M., Parsons G.C., Proctor K.J.W., Pryde D.C., and Smith N.N. |
| Journal | Tetrahedron Letters |
| Volume | 52 |
| Issue | 44 |
| Pagination | 5728 - 5732 |
| Date Published | 2011 |
| ISSN | 00404039 (ISSN) |
| Keywords | 4 amino 1,3 dihydroimidazo[4,5 c]pyridin 2 one derivative, article, carbamic acid derivative, carbonyl derivative, catalysis, cross coupling reaction, cyclization, debenzylation, diazotization, hydrogenation, microwave irradiation, Negishi cross coupling reaction, nitration, pyridone derivative, Reduction, Stille reaction, unclassified drug |
| Abstract | A flexible route which enables access to derivatives of 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-ones is described. Issues of selectivity, reaction safety, and low yields in original routes are overcome with the key improvements to the route, including a Negishi cross-coupling and use of a carbamate as a protecting group and intrinsic carbonyl source. The new route enables variation of C-6 and N-1 substituents © 2011 Elsevier Ltd. All rights reserved. |
| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-80054995309&partnerID=40&md5=c9055976d8b845e75e5ea545519a1646 |
| DOI | 10.1016/j.tetlet.2011.08.119 |
