| Title | Experimental comparison of perfusion imaging systems using multiexposure laser speckle, single exposure laser speckle and full-field laser Doppler |
| Publication Type | Conference Paper |
| Year of Publication | 2012 |
| Authors | Thompson, O., Bakker J., Kloeze C., Hondebrink E., and Steenbergen W. |
| Conference Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
| Date Published | 2012 |
| Keywords | Classifiers, Doppler effect, Dynamics, Industrial research, LASCA, Laser doppler, Laser speckle contrast, LSPI, Perfusion measurements, Speckle, Tissue |
| Abstract | A variety of laser Doppler and laser speckle contrast systems have been constructed by various groups and companies, for commercial sale and for research. All rely on the same physical phenomenon - the dynamic laser speckle pattern generated by illuminating tissue with coherent light - but differ in details of system design, operation and analysis. We present a comparison between measurements made with three systems: a multi-exposure laser speckle contrast system built at Industrial Research Ltd, a commercial single-exposure laser speckle contrast system developed by Perimed AB (PSI NR) and the full-field laser Doppler camera built by the University of Twente (TOPCam). We compare the response to changing flows of all three systems. The systems are found to produce similar results for a variety of in-vivo and in-vitro measurements. Multi-exposure speckle contrast shows some advantages in information gained and insensitivity to static speckle, at the cost of increased complexity and measurement time. © 2012 SPIE. |
| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-84860652915&partnerID=40&md5=e32f659a78ea9faf97dc095b20eb074e |
| DOI | 10.1117/12.907618 |
