Callaghan Innovation Research Papers

Back to Research Papers

TitleCytotoxic saponins from New Zealand Myrsine species
Publication TypeJournal Article
Year of Publication1994
AuthorsBloor, S.J., and Qi L.
JournalJournal of Natural Products
Pagination1354 - 1360
Date Published1994
ISSN01633864 (ISSN)
KeywordsAnimal, animal cell, Animalia, Antineoplastic Agents, Phytogenic, antiviral activity, Antiviral Agents, article, Carbohydrate Sequence, cytotoxicity, drug isolation, drug structure, leukemia cell, Magnetic Resonance Spectroscopy, Mice, Molecular Sequence Data, mouse, Myrsine, Myrsine australis, Myrsine salicina, new zealand, nonhuman, nuclear magnetic resonance, oleanolic acid derivative, plant extract, Plants, saponin derivative, Saponins, triterpene derivative, Tumor Cells, Cultured
AbstractThe observed biological activity in two New Zealand Myrsine species has been shown to be due to the presence of triterpene saponins. From Myrsine australis a series of eight oleanane-type saponins was obtained, with compounds 1-4 and 7 and 8 being novel. Also isolated were ardisiacrispin A [5] and ardisiacrispin B [6]. The structures of the new compounds were determined by chemical and spectroscopic techniques. Extracts of Myrsine salicina yielded only one saponin, 5. Saponins 1-8 were shown to be combinations of four oleanane triterpenes bonded to β-D-xylp(1→2)-β-D-glcp(1→4)-[β-D-glcp(1→2)]- α-L-arap (compounds 1,3,5,7) and this same tetrasaccharide with α-L-rhap replacing the β-D-xylp unit (compounds 2, 4, 6, 8).

Back to top