| Title | Cyclic 3-alkyl pyridinium alkaloid monomers from a new zealand haliclona sp. Marine sponge |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Damodaran, V., Ryan J.L., and Keyzers R.A. |
| Journal | Journal of Natural Products |
| Volume | 76 |
| Issue | 10 |
| Pagination | 1997 - 2001 |
| Date Published | 2013 |
| ISSN | 01633864 (ISSN) |
| Keywords | alkaloid, Alkaloids, Animals, article, bioassay, biodegradation, dehydrohaliclocyclin c, dehydrohaliclocyclin f, electrospray, energy transfer, Haliclona, heteronuclear multiple bond correlation, heteronuclear single quantum coherence, high performance liquid chromatography, Marine Biology, Mass spectrometry, Molecular Structure, monomer, natural product, new zealand, nonhuman, nuclear magnetic resonance, nuclear magnetic resonance spectroscopy, Nuclear Magnetic Resonance, Biomolecular, nuclear Overhauser effect, Oceans and Seas, Pyridinium Compounds, pyridinium derivative, unclassified drug |
| Abstract | Bioassay and NMR approaches have been used to guide the isolation of one known and two new cyclic 3-alkyl pyridinium alkaloid (3-APA) monomers from the New Zealand marine sponge Haliclona sp. The new compounds, dehydrohaliclocyclins C (3) and F (4), are the first reported examples of cyclic 3-APA monomers with unsaturation in the alkyl chain. The known compound haliclocyclin C (2) was also isolated from a mixture with 4. The structures of compounds 2-4 were elucidated using NMR spectroscopy, mass spectrometry, and chemical degradation. © 2013 The American Chemical Society and American Society of Pharmacognosy. |
| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-84886814363&partnerID=40&md5=8739dd259036629087b95182c8b59c61 |
| DOI | 10.1021/np400661c |
