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TitleCyclic 3-alkyl pyridinium alkaloid monomers from a new zealand haliclona sp. Marine sponge
Publication TypeJournal Article
Year of Publication2013
AuthorsDamodaran, V., Ryan J.L., and Keyzers R.A.
JournalJournal of Natural Products
Pagination1997 - 2001
Date Published2013
ISSN01633864 (ISSN)
Keywordsalkaloid, Alkaloids, Animals, article, bioassay, biodegradation, dehydrohaliclocyclin c, dehydrohaliclocyclin f, electrospray, energy transfer, Haliclona, heteronuclear multiple bond correlation, heteronuclear single quantum coherence, high performance liquid chromatography, Marine Biology, Mass spectrometry, Molecular Structure, monomer, natural product, new zealand, nonhuman, nuclear magnetic resonance, nuclear magnetic resonance spectroscopy, Nuclear Magnetic Resonance, Biomolecular, nuclear Overhauser effect, Oceans and Seas, Pyridinium Compounds, pyridinium derivative, unclassified drug
AbstractBioassay and NMR approaches have been used to guide the isolation of one known and two new cyclic 3-alkyl pyridinium alkaloid (3-APA) monomers from the New Zealand marine sponge Haliclona sp. The new compounds, dehydrohaliclocyclins C (3) and F (4), are the first reported examples of cyclic 3-APA monomers with unsaturation in the alkyl chain. The known compound haliclocyclin C (2) was also isolated from a mixture with 4. The structures of compounds 2-4 were elucidated using NMR spectroscopy, mass spectrometry, and chemical degradation. © 2013 The American Chemical Society and American Society of Pharmacognosy.

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